The Matrix Dynamics Group was established in 1973 with funding from the Medical Research Council of Canada, now known as Canadian Institutes of Health Research. Originally the group focused on the regulation of cells from the periodontium and was known as the MRC group in Periodontal Physiology. The group currently consists of 5 principal investigators and focuses on the regulation of connective tissue matrix proteins in health and disease. The Group's major strength is in bringing a full spectrum of scientific and technical experience to the issues of matrix remodeling and the signaling networks that control remodeling.