It has to be the av: myofibroblast integrins activate latent TGF-ß1

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Hinz_Acccepted_NV12.13.pdf (217.21 KB)

Date

2013-12-05

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Nature Publishing Group

Abstract

Cell-mediated activation of latent TGF-β1 is a key promoting event in fibrosis in all organs. A new study shows that specific targeting of the αv subunit of integrins in fibrogenic myofibroblasts effectively reduces developing and established fibrosis in liver, kidneys and lungs (pages 1617–1624).

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Nat Med. 2013 Dec 5;19(12): 1567-8.

URI

http://hdl.handle.net/1807/69587

DOI

http://doi.org/10.1038/nm.3421

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Matrix Dynamics Group
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