Ras-guanine nucleotide releasing factors 1 and 2 interact with PLC? at focal adhesions to enable IL-1-induced Ca2+ signaling, ERK activation and MMP-3 expression.

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TSPACE_Ras-guanine_nucleotide_releasing-2013.pdf (1.7 MB)

Date

2013-02

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Publisher

Portland Press

Abstract

Interleukin-1 (IL-1) signaling in anchorage-dependent cells involves focal adhesion-restricted and Ca2+-dependent Ras and extracellular signal-related kinase (ERK) activation that lead to MMP release and extracellular matrix remodeling. Ras activity is regulated in part by the Ca2+-responsive Ras guanine-nucleotide-releasing factors 1 and 2 (Ras-GRF1/2), but the mechanisms that link and localize IL-1-induced Ca2+ signaling to focal adhesions are not defined. Herein we characterized the role of Ras-GRF1/2 in Ca2+ and Ras􀵺ERK signaling after IL-1 stimulation.

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The final version of this article is available here www.biochemj.org/bj/449/0771/bj4490771.htm.

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Citation

Biochem J. 2013 Feb 1;449(3):771-82.

URI

http://hdl.handle.net/1807/67758

DOI

http://doi.org/10.1042/BJ20121170

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Matrix Dynamics Group
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