Spleen-colony formation in anemic mice of genotype WWv

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Science_1964_144_844.pdf (337.24 KB)

Date

1964-05-15

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American Association for the Advancement of Science

Abstract

The hemopoietic cells from anemic mice of genotype WWv are less able by 200-fold to take part in colony formation in the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice form colonies in the spleens of unirradiated mice of genotype WWv. Use of animals of genotype WWv as recipients improves the spleen-colony method by removing bias resulting from the death of irradiated recipients.

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A version of the published article is available for those with access to JSTOR, via: http://tinyurl.com/6ewt3

Keywords

assay for progenitor cells, CFU, colony-forming units, genetics, genotype, hematopoietic progenitor cells, hematopoietic stem cells, hematopoietic stem cell transplantation, inbred mouse strains, mouse marrow, mouse spleen, spleen colonies

Citation

Science 1964(15 May); 144(1620): 844-846.

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http://hdl.handle.net/1807/2774

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Stem Cells
Till, James E.
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