2022

Permanent URI for this collectionhttps://hdl.handle.net/1807/109465

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Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8
(Canadian Science Publishing, 2022-12-10) Li, Zhenshu; Cai, Ke; Sun, Yue; Zhou, Dezheng; Yan, Jing; Luo, Suhui; Huang, Guowei; Gao, Yuxia; Li, Wen
Folic acid (FA) could improve cognitive performances and attenuate brain cell injury in the aging brain, FA supplementation is also associated with inhibiting neural stem cells (NSCs) apoptosis. However, its role in age-associated telomere attrition remains unclear. We hypothesized that FA supplementation attenuates age-associated apoptosis of NSCs via alleviating telomere attrition in senescence-accelerated mouse prone 8 (SAMP8). In this study, 4-month-old male SAMP8 mice were assigned equal numbers to four different diet groups (n=15). Fifteen age-matched senescence-accelerated mouse resistant 1 (SAMR1) (Con-R) were used as the standard aging control group, feeding the FA-normal diet. After folic acid treatment 6-month, all mice were sacrificed. NSCs apoptosis, proliferation, oxidative damage and telomere length have been evaluated by immunofluorescence and Q-fluorescent in situ hybridization. The results showed that FA supplementation inhibited age-associated NSCs apoptosis and prevented telomere attrition in the cerebral cortex of SAMP8 mice. Importantly, this effect might be interpreted by the decreased levels of oxidative damage. In conclusion, we demonstrate it may be one of the mechanisms that FA inhibiting age-associated NSCs apoptosis by alleviating telomere length shortening.
Breastfeeding in Canada: predictors of initiation, exclusivity, and continuation from the 2017-18 Canadian Community Health Survey
(Canadian Science Publishing, 2022-12-23) Chan, Kathleen; Labonté, Jocelyne M; Francis, Jane; Zora, Haley; Sawchuk, Sandra L; Whitfield, Kyly C
Human milk is the ideal source of nutrition for infants, however adherence to breastfeeding recommendations is suboptimal and availability of Canadian breastfeeding data is limited. Using the 2017-2018 Canadian Community Health Survey Public Use Microdata File (Maternal Experiences Module, n=5,558, weighted n=1,669,462) we computed breastfeeding indicators, and explored sociodemographic, health and geographical predictors of breastfeeding with univariate logistic regression models. Nationally, of all participants who gave birth in the preceding 5 years, 91% initiated breastfeeding, 43% exclusively breastfed to ≥5 months and 35% to ≥6 months, 56% reported any breastfeeding at ≥6 months, and 31% reported breastfeeding at ≥12 months. Breastfeeding cessation was most commonly attributed to insufficient milk supply (25%), but reasons differed significantly by breastfeeding duration. Breastfeeding initiation, exclusivity for ≥5 months, and extended ≥12 months all differed by geographic region, and by most sociodemographic and health characteristics. Positive breastfeeding outcomes were highest in British Columbia, and lowest in Quebec and the Atlantic region, and generally higher if caregivers had recently immigrated to Canada, were married, >30 years of age, not White, non-smoking, had completed post-secondary education, and had an annual household income >$40,000. These disparities indicate the need for tailored, equitable approaches to breastfeeding support, and continued regional monitoring of breastfeeding outcomes.
Post-exercise endothelial function is not associated with extracellular vesicle release in healthy young males.
(Canadian Science Publishing, 2022-11-17) Tryfonos, Andrea; Cocks, Matthew; Browning, Nicola; Dawson, Ellen Adele
Acute exercise can result in temporary decrease in endothelial function, which may represent a transient period of risk. Numerous mechanisms underpin these responses included release of extracellular vesicles (EVs) derived from apoptotic or activated endothelial cells and platelets. This study aimed to compare the time-course of endothelial responses to two exercise protocols: moderate-intensity-continuous-exercise (MICE) and high-intensity-interval-exercise (HIIE) and the associations with EV release. Eighteen young healthy males (age: 22.6±3.7y, BMI: 25.6±2.5m2/kg, VO2peak: 38.6±6.5ml/kg/min) completed two randomly assigned exercises; HIIE (10x1min-@-90% heart rate reserve (HRR), 1min passive recovery) or MICE (30min-@-70% HRR) on a cycle ergometer. FMD was used to assess endothelial function and blood samples were collected to evaluate endothelial cell-derived EV (CD62E+) and platelet-derived EV (CD41a+), prior- and 10, 60, and 120min post-exercise. There were similar increases, but different time-courses (P=0.017) in FMD (increased 10min post-HIIE, P
The day-to-day reliability of residual force enhancement during voluntary and electrically stimulated contractions
(Canadian Science Publishing, 2022-12-02) Jacob, Kaitlyn B. E.; Hinks, Avery; Power, Geoffrey Alonzo
Residual force enhancement (rFE) is characterized by increased steady-state isometric force following active muscle lengthening compared to a fixed-end isometric contraction at the same muscle length and level of neuromuscular activation. Many studies have characterized rFE in humans; however, the day-to-day reliability of rFE is unclear. We aimed to examine day-to-day reliability of rFE across various contraction types in the dorsiflexors in males and females. Twenty-five recreationally active young adults completed 2 visits, 1 week apart. Following determination of maximum voluntary contraction (MVC) strength, rFE was assessed during maximal voluntary effort, 20% MVC electrically stimulated, and 20% MVC torque-matching conditions. Each rFE condition was completed at 2 joint excursions: 0-20º plantar flexion (PF) and 0-40ºPF. Intraclass correlation coefficients (ICC) assessed relative reliability, and typical error of measurement (TEM), and the correlation variability of TEM (CVTEM) assessed absolute reliability. Electrically stimulated contractions demonstrated the highest reliability at 40ºPF (ICC:0.9; CVTEM:22.8 %) and 20ºPF (ICC:0.8; CVTEM:34.3 %), followed by maximal voluntary contractions at 40ºPF (ICC:0.7; CVTEM:55.1%) and 20ºPF (ICC:0.1; CVTEM:81.1%). The torque-matching trials showed poor reliability for 20º and 40ºPF (ICC: -0.1-0.3; CVTEM: 118.1 %-155.2 %). Our results demonstrate higher reliability of rFE when stretching to the descending limb of the torque-angle relationship compared to the plateau region, and in electrically stimulated compared to voluntary contractions in the dorsiflexors for both males and females.
Fast food consumption in adults living in Canada: Alternative measurement methods, consumption choices and correlates
(Canadian Science Publishing, 2022-10-14) Seale, Emily; de Groh, Margaret; Greene-Finestone, Linda S.
Global industries and technological advancements have contributed to the proliferation of fast food (FF) establishments and ultra-processed food, associated with poorer diet quality and health outcomes. To investigate FF as an indicator, we compared alternative methods to capture self-reported FF consumption and examined associated socio-demographic factors. We conducted a secondary analysis of the 2014-2015 Foodbook study, a cross-sectional survey on foods consumed by Canadians during the previous week. An embedded randomized design compared alternative FF intake questions of varying detail. 6,062 participants aged 18+ were included, representing 24.7 million Canadian adults. Approximately 48% consumed FF in the past week, and of FF consumers, average frequency was twice. Asking broadly about FF intake without examples resulted in significantly lower reported FF intake compared to the two more detailed questions; the latter two were not significantly different. Burgers, pizza, and submarines/sandwiches were most commonly consumed. Men, younger age, higher BMI, women in central Canada (versus territorial regions) and men with income $30,000-$80,000 (versus >$80,000) were associated with higher FF consumption. Consumption of FF is common among Canadians; some associated factors are gender-specific. Further research examining FF as an indicator, and individual and societal implications of FF consumption is recommended to inform programs and policies.
We want more! Examining the perceived training and information needs of health and fitness practitioners about disability and physical activity
(Canadian Science Publishing, 2022-10-05) Leo, Jennifer; Tomasone , Jennifer R; Bassett-Gunter, Rebecca; Knibbe, Tara Joy; Latimer-Cheung, Amy E.
A lack of disability-specific knowledge among practitioners poses a significant barrier to physical activity (PA) participation for persons with physical disabilities (PWPD). This study aimed to identify perceived training needs of health and fitness practitioners to support PA for PWPD. Canadian health and fitness practitioners (n=115; 81% female) completed an online survey. More specialized training and access to information about PA for PWPD is needed. In-person training, webinars and lived experiences of PWPD are recommended.
Test-retest repeatability of electrically-evoked isotonic power and isometric torque in the plantar flexors
(Canadian Science Publishing, 2022-10-28) Paris, Michael T.; Zero, Alexander M.; Rice, Charles L.
Electrically-evoked isometric torque has good to excellent repeatability, but the degree of repeatability for electrically-evoked isotonic power is unknown. We evaluated the test-retest repeatability of plantar flexion isometric torque and isotonic power evoked using brief tetanic trains at 10 Hz and 50 Hz. Both torque and power had excellent (intraclass correlation coefficient >0.9) repeatability at low and high frequencies. Similar to isometric torque, electrically-evoked isotonic power is a stable measure for studying dynamic muscle function.
Applying suggested new terminology and definitions for human milk feeding in the Alberta Pregnancy Outcomes and Nutrition (APrON) longitudinal pregnancy cohort
(Canadian Science Publishing, 2022-08-12) Jarman, Megan; Shen, Ye; Yuan, Yan; Madsen, Mette; Robson, Paula J; Bell, Rhonda C
The complexity of human milk feeding behaviours may not be captured using simpler definitions of ‘exclusive’ and ‘non-exclusive’ breastfeeding. New definitions have been suggested to describe variation in these behaviours more fully but have not been widely applied. We applied the new definitions to data derived from 3-day human milk feeding diaries. Participants (n=1091) recorded the number, beginning/end time, and modes of feeding of infants aged 3 months. Data were used to create six exclusive groups according to feeding mode(s): 1) human milk at-breast only; 2) human milk at-breast and human milk in a bottle; 3) human milk at-breast and infant formula in a bottle; 4) human milk at-breast and human milk and infant formula mixed in the same bottle; 5) human milk at-breast, human milk in a bottle, and infant formula in a bottle (not mixed); 6) a bottle that sometimes contained human milk and sometimes infant formula (not mixed); never at-breast. Differences in maternal and infant characteristics were examined among groups. Fifty-seven percent fed at-breast only (Group 1). Those in Group 1 spent a similar amount of time feeding directly at-breast (median 132 (IQR 98-172 ) min/day) as those in Groups 2 (124 (95-158)), 3 (143 (100-190)) and 5 (114 (84-142)) (p>0.05) indicating that adding bottle-feeding did not always reduce the time infants were fed at-breast. Applying new suggested definitions to describe human milk feeding behaviours from the mothers’ perspective highlights the complexity of patterns used and warrants further application and research to explore impacts on health outcomes.
Knowledge and perceptions of the 2019 Canada’s Food Guide: A qualitative study with Canadian children
(Canadian Science Publishing, 2022-09-06) Zhang, Flora; Laila , Amar; Leme, Ana Carolina; Ma, David W.L.; Haines, Jess; , the Guelph Family Health Study
To support Canadians ages 2 years and older in improving their dietary intake, Health Canada released a revised Canada’s Food Guide (CFG) in 2019. This study aimed to explore the knowledge and perceptions of the 2019 CFG among children ages 9–12 years old from Southwestern Ontario. From September–November 2021, interviews were conducted with children by video conference. Thirty-five children (50% girls, 80% White; mean age 9.9 years) participated. Data were analyzed using a hybrid thematic approach with inductive and deductive analyses. Many children expressed a lack of knowledge on certain foods (i.e., plant-based proteins, whole grains, highly processed foods) that are highlighted in the CFG. Children also expressed confusion around food groups, including recommended proportions and categorization of some foods (e.g., dairy products, plant-based proteins). Children generally expressed positive perceptions regarding CFG and its eating habit recommendations, i.e., “Cook more often”, “Eat meals with others”, and “Enjoy your food”, and they suggested strategies to improve adherence to these recommendations, including providing children more responsibility and independence with food preparation tasks and minimizing family time conflicts. Children’s perceptions of the CFG can help inform public health policies and programmatic strategies designed to support children's food choices and eating habits.
Many authors of publicly-available top-selling nutrition books in Canada are without clinical nutrition credentials, do not cite evidence, and promote their own services or products
(Canadian Science Publishing, 2022-09-23) Loung, Chao-Yu; Sarfaraz, Sidra; Carew, Allie S; MacKay, Dylan S.; Cahill, Leah E
The accuracy of books as public nutrition resources varies substantially; whether authors of publicly available nutrition books possess related experience, cite scientific evidence, or have other financial incentives has not been assessed thoroughly. This study aimed to determine if publicly available top-selling nutrition books are written by authors who (1) have relevant expertise, (2) cite scientific evidence, and (3) benefit financially in other ways. Best-selling nutrition books were gathered from Amazon Canada. Differences in scientific citations and financial incentives were compared between authors with and without credentials. Authors who were Doctor of Medicine (MD), registered dietitians (RD), chiropractors (DC), or naturopathic doctors (ND) had more in-text citations (56% versus 25%, p=0.014) and cited more scientific articles (83% versus 50%, p=0.0045) compared to all other authors. The majority of authors of publicly-available top-selling nutrition books in Canada did not have MD/RD credentials. Many of the authors promoted their own services or products, regardless of credentials.
MoveStrong at Home: A feasibility study of a model for remote delivery of functional strength and balance training combined with nutrition education for older pre-frail and frail adults.
(Canadian Science Publishing, 2022-08-31) Wang, Ellen; Keller, Heather H.; Mourtzakis, Marina; Rodrigues, Isabel Braganca; Steinke, Alex; Ashe, Maureen C; Thabane, Lehana; Brien, Sheila; Funnell, Larry; Cheung, Angela; Milligan, James; Papaioannou, Alexandra; Weston, Zachary J; Straus, Sharon; Giangregorio, Lora
Exercise and nutrition interventions are often recommended for frailty; however, effective strategies are required for real-world implementation. Our primary aim was to assess the feasibility and acceptability of telephone and virtual delivery of MoveStrong, an 8-week exercise and nutrition program with a 4-week follow-up for older pre-frail and frail adults. A priori criteria for success included: recruitment (≥25/12 weeks), retention at follow-up (≥80%), and adherence to exercise and nutrition sessions (≥70%). We recruited community-dwelling Ontario residents; ≥60 years, ≥1 chronic condition, ≥1 FRAIL scale score. Participants received mailed materials, a personalized exercise program, eleven remote one-on-one training sessions with an exercise physiologist and three online dietitian-led nutrition education sessions. We completed exploratory analyses of secondary outcomes including physical function and dietary protein intake. Semi-structured interviews supported program evaluation. In total, 30 participants were enrolled. 28 (93%) participants completed program and follow-up assessments. Adherence to exercise and nutrition sessions (CI) was 84% (77-91%) and 82% (70-93%) respectively. At program end and follow-up [mean change (CI)], significant improvements were measured in 30-second chair stand test [3.50 (1.12–5.86), 4.54 (1.94–7.13) chair stands] and dietary protein intake [12.9 (5.7–20.0), 9.2 (0.4–18.1) g]. Overall, participants were satisfied with program delivery. Trial registration number: NCT04663685.
Physiological responses to ramp-incremental cycling tests performed at three simulated altitudes: A randomized crossover trial
(Canadian Science Publishing, 2022-09-06) Beever, Austin T; Zhuang, Andrea; Aboodarda, Saied Jalal; Murias, Juan M; MacInnis, Martin J.
Hypoxia negatively impacts aerobic exercise, but exercise testing in hypoxia has not been studied comprehensively. To determine the effects of simulated altitude on the gas exchange threshold (GET), respiratory compensation point (RCP), and maximal oxygen uptake (V̇O2max), 24 participants (mean [SD]; 26 [4] years; 171.6 [9.7] cm; 69.2 [11.9] kg) acclimatized to mild altitude (~1100 m) performed three cycling ramp-incremental exercise tests (with verification stages performed at 110 % of peak power output (PPO)) in simulated altitudes of 0m (SL), 1111m (MILD), and 2222m (MOD), in a randomized order. There were significant effects of condition (i.e., fraction of inspired oxygen [(FIO2]) for GET (p=0.001), RCP (p
The Importance of Collaboration Between Medical and Exercise Professionals in Addressing Patient Physical Inactivity
(Canadian Science Publishing, 2022-10-19) Bray, Nick W; O'Brien, Myles W.; Wong, Michelle; Sui, Wuyou; Voss, M. Lauren; Turnbull, Nolan; Nagpal, Taniya S; Fowles, Jonathon R
Physical activity has declined further during the COVID-19 pandemic. Physicians are at the front lines of proactively educating and promoting physical activity to patients; however, physicians do not feel confident and face numerous barriers in prescribing exercise to patients. Exercise referral schemes, comprised of collaborations with qualified exercise professionals, represent a fruitful option for supporting physicians hoping to promote physical activity to more patients. Herein, we provide practical suggestions for establishing and creating a successful referral scheme. Ultimately, exercise referral schemes offer an alternative to help physician burnout and mitigate patient physical inactivity during and beyond the COVID-19 pandemic.
Higher- and lower-load resistance exercise training induce load-specific local muscle endurance changes in young women: a randomised trial
(Canadian Science Publishing, 2022-08-22) Fliss, Matthew D; Stevenson, Jordan; Mardan-Dezfouli, Sobhan; Li, Donna C. W.; Mitchell, Cameron J
The effect of resistance training with higher- and lower-loads on muscle mass and strength has been extensively studied while changes in muscle endurance have received less attention. This trial aimed to assess the effect of training load on absolute (AME) and relative muscle endurance (RME). Sixteen untrained women (22.7±3.3 yr: mean ± SD) had one arm and leg randomly assigned to train with higher-loads (HL; 80-90% 1RM), and the contralateral limbs trained with lower-loads (LL; 30-50% 1RM) thrice weekly to volitional fatigue for 10 weeks. Heavy and light load AME and RME, strength, and muscle mass were assessed pre- and post-training. Strength increased more in the HL compared to LL leg (P =
Association between adherence to plant-based dietary patterns and obesity risk: a systematic review of prospective cohort studies
(Canadian Science Publishing, 2022-06-27) Jarvis, Sarah Elizabeth; Nguyen, Michelle; Malik, Vasanti
The worldwide prevalence of obesity and its co-morbidities is staggering, and elevated body mass index represents a leading risk factor of death globally. Consistent evidence demonstrates a high-quality plant-based diet as an effective intervention for weight management, although it may be particularly challenging to adopt in its entirety for habitual meat consumers or individuals with especially poor-quality diets. Plant-based diets are increasingly studied using indices such as the overall plant-based diet index (PDI), healthful PDI, and unhealthful PDI, which offer more flexibility than a binary classification of vegetarianism and better facilitate translation into dietary recommendations. We summarized these recently accumulated studies to comprehensively evaluate plant-based diets in relation to obesity risk. We searched Medline, Embase, and CINAHL databases through January 2022 and identified 9 prospective adult cohorts. Reporting of results was consistent with PRISMA guidelines and certainty of the evidence was assessed using domains from GRADE. The PDI had a protective association with body weight gain and adiposity. Emphasis of healthful plant foods strengthened this association and emphasis of unhealthful plant foods demonstrated either a positive or null association. The certainty of the evidence was considered moderate. These findings have wide application to inform dietary interventions and sustainable policy recommendations. Prospero ID: CRD42020198143.
Perceived exertion and dyspnea while cycling during a hypoxic and hyperoxic placebo
(Canadian Science Publishing, 2022-08-24) Kipp, Shalaya; Leahy, Michael G.; Hanna, Jacob A.; Sheel, Andrew William
Rating of Perceived Exertion (RPE) is used to subjectively quantify the perception of physical activity, breathlessness or dyspnea, and leg discomfort (RPElegs) during exercise. However, it is unknown how dyspnea or RPElegs can be influenced by expectations. Thirty healthy, active participants (19 M, 11 F) completed five, 5-minute submaximal cycling trials at 60% peak work rate. We deceived participants by telling them they were inspiring different hypoxic and hyperoxic gases, when in fact they breathed room air. Cardiorespiratory variables were similar between the trials, however dyspnea and RPElegs evaluated with a Borg scale changed in a dose-response manner. When participants believed they were breathing 15% O2, they significantly increased dyspnea +0.70 ± 0.2 units (p=0.03) compared to room air, whereas RPElegs was unchanged +0.35 ± 0.1 units (p=0.70). When comparing 15% O2, to the 23% hyperoxic condition, where participants significantly increased their dyspnea +1.05 ± 0.4 units (p=0.003) but did not significantly change RPElegs +0.55 ± 0.2 units (p=0.46). We found that dyspnea during exercise is susceptible to expectancy, without any accompanying physiological changes. Given coaches and clinicians uses perceived exertion to prescribe exercise intensity and evaluate treatments, our finding show that the effect of expectations must be considered when interpreting sensations of breathlessness.
Annual Gatherings as an Integrated Knowledge Translation Strategy to Support Local and Traditional Food Systems Within and Across Indigenous Community Contexts: A Qualitative Study
(Canadian Science Publishing, 2022-07-04) Valaitis, Renata; McEachern, Louise W.; Harris, Sandra Annette; Dick, Tania; Yovanovich, Joanne; Yessis, Jennifer; Zupko, Barbara; Corbett, Kitty K.; Hanning, Rhona M.
Integrated knowledge translation (IKT) and community-based participatory research are recognized as effective approaches when Indigenous and non-Indigenous partners work together to focus on a common goal. The ‘Learning Circles: Local Healthy Food to School’ (LC:LHF2S) study supported the development and implementation of Learning Circles (LC) in four Canadian Indigenous communities with the goal of improving local, community-based healthy foods systems. Critical to the research process were Annual Gatherings (AG) where diverse stakeholders (researchers, Indigenous community members and partners) visited each community to share knowledge, experiences, and provide support in the research process. Using a qualitative, descriptive method, this paper explores how the AG supported IKT across partners. Yearly interviews involving 19 total participants (with some participating multiple times across the four gatherings) elicited their AG experiences in supporting local LC:LHF2S. Three themes with multiple sub-themes were identified: a) setting the stage for IKT (importance of in-person gatherings for building relationships across partners, learning from each other), b) enabling meaningful engagement (aligning research with Indigenous values, addressing tensions and building trust over time, ensuring flexibility, and Indigenous involvement and leadership), and c) supporting food system action at the local level (building local community engagement and understanding, and integrating support for implementation and scale up of LC). This paper provides useful and practical examples of the principles of Indigenous-engaged IKT and CBPR in action in healthy, local and traditional food initiatives. AG are a valuable IKT strategy to contribute to positive, transformative change and ethical research practice within Indigenous communities.
Sports Nutrition Knowledge in Athletes with a Spinal Cord Injury and Coaches of Para Sports
(Canadian Science Publishing, 2022-08-21) Madden, Robyn Frances; Lalonde-Bester, Sophie; Manocha, Ranita; Martin, Julia; Flueck, Joelle Leonie; Hertig-Godeschalk, Anneke; Shearer, Jane; Parnell, Jill A.
Sports nutrition for athletes with a spinal cord injury (SCI) is complex, making it challenging for athletes to stay informed. The aim of this study was to assess sports nutrition knowledge in athletes with a SCI and coaches of para sports. The secondary aim was to report sources of sports nutrition information. Eighty athletes and twenty-six coaches across various adapted sports were recruited. The Nutrition for Sport Knowledge Questionnaire was used to assess nutrition knowledge for both groups. Athletes achieved their highest score among the alcohol (65 ± 19%) category and the lowest in sports nutrition (43 ± 17%). Coaches demonstrated the most knowledge in the alcohol (73 ± 17%) category and lowest knowledge in the supplementation (45 ± 19%) category. Both groups relied on the internet, dietitians, and coaches for sports nutrition information. Future studies should explore the effects of nutrition education on nutrition knowledge and dietary intakes among these populations.
Guidance and perspectives on highly processed foods
(Canadian Science Publishing, 2022-07-27) Panahi, Shirin; Jones, Wendelyn; Duncan, Alison M.; Ferland, Guylaine; Keller, Heather H.; Grantham, Andrea; House, James D
Guidance from Health Canada to limit highly processed foods (HPF) seeks to ensure that Canadians remain within intake recommendations for nutrients of concern. However, HPF can contribute to dietary requirements of specific populations. The Canadian Nutrition Society and Institute for the Advancement of Food and Nutritional Sciences convened speakers for a Food for Health workshop in 2021 to provide evidence and perspectives from government, industry, and healthcare on reasons for advocating limits and potential unintended consequences of limiting HPF, and implications and necessity of HPF in clinical settings. This paper discusses advantages and disadvantages of HPF explored at this workshop.
The association of objectively and subjectively measured physical activity and sedentary time with prediabetes and type 2 diabetes in adults: A cross-sectional study in Framingham Heart Study cohorts
(Canadian Science Publishing, 2022-07-08) Pooni, Rubin; Edgell, Heather; Tamim, Hala; Kuk, Jennifer L
The purpose of this study was to examine whether using both objectively (accelerometer) and subjectively (questionnaire) measured moderate- to vigorous-intensity physical activity (MVPA) and sedentary time (SED) improves the prediction of prediabetes and type 2 diabetes (pre/T2D) using data from the Framingham Heart Study (n=4200). Logistic regression was used to examine the odds ratio of pre/T2D in groups cross-classified by subjective and objective MVPA and SED. Less than half of participants fell into concordant categories of MVPA and SED using subjective and objective measures, with 7.0-9.4% of participants in the extreme discordant categories of high-low or low-high subjective-objective MVPA or SED. Low objective MVPA, regardless of subjective MVPA status, was associated with a higher prevalence of pre/T2D (P

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