Canadian Science Publishing

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Canadian Science Publishing (CSP) is committed to enhancing the reach, rigour, and relevance of science so that people can find, trust, and use it. Established in 1929, Canadian Science Publishing is Canada’s largest not-for-profit publisher and has grown to publish 22 international scientific journals across natural and physical sciences and engineering, including three open access journals. Canadian Science Publishing is dedicated to enhancing the integrity, relevance, and impact of research globally, while promoting open science, diversity, and sustainability. Committed to equitable access, Canadian Science Publishing partners with over 25 scientific societies to remove barriers and empower the global research community. For more information, please visit www.cdnsciencepub.com.

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00Ar134-1, a spring wheat line of intergeneric origin
(Canadian Science Publishing, 2016-05-19) Brar, Gurcharn Singh; Hucl, Pierre
00Ar134-1 is an intergeneric spring wheat line derived from Elymus repens (quack grass). The line was developed as a potentially new source of resistance to Fusarium head blight (FHB) of wheat. 00Ar134-1 is resistant to Fusarium head blight and as well as leaf rust, stem rust, and common bunt. Although lower yielding and taller than commercial cultivars, this line is of similar maturity and kernel weight. 00Ar134-1 can potentially be used as a resistant parent for improving Fusarium head blight resistance in common wheat.
1 E-Cadherin knockdown induces cancer stem cell-like phenotype and drug resistance
(Canadian Science Publishing, 2021-02-05) Sharma, Anuka; Kaur, Harmandeep; De, Renaissa; Srinivasan, Radhika; Pal, Arnab; Bhattacharyya, Shalmoli
Cervical cancer is one of the leading causes of mortality amongst women in developing countries and therapy resistance is the main reason for its treatment failure. Recent advances suggest that cancer stem cells (CSCs) are critically involved in regulating the chemo resistant behavior of cervical cancer cells. In our study the CSC phenotype cells were isolated and the expression of stem cell marker and epithelial-mesenchymal transition (EMT) associated gene was confirmed by various assays. However, these CSC phenotype cells cannot be cultured for further cytotoxicity studies. So, we tried to establish a CSC model in cervical cancer cells. We performed the siRNA-mediated knockdown of E-cadherin (E-cad) in these cells and studied EMT associated stem cell-like properties in them. We also performed dose dependent cell viability assay using clinically relevant drugs such as cisplatin, cyclopamine and GANT58 to analyze the drug resistant behavior of these cancer cells. We found that E-cad knockdown induces EMT in cervical cancer cells imparting stem-cell like characteristics along with enhanced tumorsphere formation, migration, invasion ability and drug resistance. This is the first study to establish a CSC model in cervical cancer cells by knockdown of E-cad which can be utilized for development of anti-cancer therapies.
1,2,4-triazole derivatives with morpholine; DFT study and Antileishmanial activity
(Canadian Science Publishing, 2017-12-18) Süleymanoğlu, Nevin; Ustabaş, Reşat; Direkel, Şahin; Bingöl Alpaslan, Yelda; Ünver, Yasemin
1,2,4-triazole derivatives with morpholine; 4-((3-methylthiophene–2-yl)methylenamino)-1-((4-(3-methylthiophene–2-yl)methylene amino)-1-(morpholinomethyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl)-3-(thiophene–2-ylmethyl)-1H-1,2,4-triazole-5(4H)-one (compound I) and 1-((1-(morpholinomethyl)–4-(5-nitrothiophene–2-yl)methyleneamino)-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl)-4-((5-nitrothiophene–2-yl)methyleneamino)-3-(thiophene–2-ylmethyl)-1H-1,2,4-triazole-5(4H)-one (compound II), were optimized using a density functional theory (DFT) method with 6-311G(d,p) basis set and structural and spectral parameters were determined. In vitro antileishmanial activities of compounds were performed against Leishmania infantum promastigots by microdilution broth assay with Alamar Blue dye. Amphotericin B was used as standard drug. The results show that both compounds are antiparasitic and especially compound II has considerable antileishmanial activity due to the minimal inhibitory concentration value of 312 μg/mL.
1,2-Dichloroethane induced hepatotoxicity and apoptosis by inhibition of ERK 1/2 pathways
(Canadian Science Publishing, 2018-01-09) Pang, Yaqin; Qi, Guangzi; Jiang, Sili; Zhou, Ying; Li, Wenxue
1,2-Dichloroethane (DCE) is a ubiquitous occupational environmental contaminant. Subacute exposure of DCE could cause severe toxic encephalopathy and obvious toxic effects on the liver. However, the toxicity of DCE on liver and the molecular mechanism still remain elusive. In the present study, we established a DCE-exposed animal model by inhalation in SD rats and used HepG2 cells in in vitro tests. Hepatic dysfunction was found in DCE-exposed groups compared with the control group. Moreover, apoptotic cells and the decreased phosphorylation of ERK1/2 were found in liver tissue of rats in three DCE-exposed groups. In in vitro tests, we also found that short-term exposure to DCE induced apoptosis in HepG2 cells. Furthermore, the incubation of cells with DCE significantly decreased the phosphorylation of ERK1/2 in a concentration-dependent manner. Additionally, the incubation of HepG2 cells with the ERK1/2 activator EGF significantly increased apoptosis in HepG2 cells. In conclusion, our results suggested that DCE induced apoptosis in HepG2 cells by inhibition of ERK1/2 pathways.
1,2-Dihydro-1,3,2-diazaborinine tautomer as an electron-pair donor in hydrogen-bonded complexes
(Canadian Science Publishing, 2021-06-17) Alkorta, Ibon; Elguero, Jose; Del Bene, Janet E
Ab initio MP2/aug’-cc-pVTZ calculations have been carried out to investigate 1,2-dihydro-1,3,2-diazaborinine:HX complexes for HX = H+, HF, HCl, H2O, HCN, NH3, HCP, and HCCH. Most complexes are stabilized by linear, traditional hydrogen bonds except for those with H2O and NH3 which have bridging structures and nonlinear hydrogen bonds. H-atom transfer from N to B can occur in complexes with HF and HCl, with formation of a traditional F-H…N and a proton-shared Cl…H…N bond. The binding energies of the uncharged complexes range from 25 to 88 kJ.mol–1. Spin-spin coupling constants have been used to characterize these hydrogen-bonded complexes. Des calculs ab initio MP2/aug'-cc-pVTZ ont t effectus pour tudier les complexes 1,2-dihydro-1,3,2-diazaborinine:HX pour HX = H+, HF, HCl, H2O, HCN, NH3, HCP et HCCH. La plupart des complexes sont stabiliss par des liaisons hydrogne traditionnelles, linaires, l'exception de celles avec H2O et NH3 qui ont des structures pont et des liaisons hydrogne non linaires. Le transfert de l'atome d'hydrogne de N B peut se produire dans des complexes avec HF et HCl, avec formation d'une liaison F-HN traditionnelle et d'une liaison ClHN avec un proton comparti. Les nergies de liaison des complexes non chargs vont de 25 88 kJmol–1. Des constantes de couplage spin-spin ont t utilises pour caractriser ces complexes liaison l'hydrogne.
1-Methylcyclopropene affects shelf-life quality of controlled atmosphere stored ‘Cold Snap’ pears
(Canadian Science Publishing, 2018-08-21) Flaherty, Edward J; DeEll, Jennifer R.; Shelp, Barry J; Bozzo, Gale
1-Methylcyclopropene (1-MCP) and controlled atmosphere (CA; elevated CO2 and low O2 partial pressures) preserve the overall quality of ‘Cold Snap’ pears during low temperature storage, including minimizing physiological disorders. In two separate years, we determined the impact of 1-MCP (0 or 300 nL L
105Tc nuclear structure and systematic evolution of states of 1/2+[431] intruder band in odd-A 95, 97,99,101,103,105,107Tc isotopes
(Canadian Science Publishing, 2020-06-15) Zeghib, Sadek
Previously observed negative and positive parity states of 105Tc were studied in the framework of the particle-rotor model. Transition properties and experimental energies were compared to the predictions of model calculations. A systematic study of the evolution of the intruder π1/2+[413] band in the nuclear structure of odd-A technetium isotopes 95,97,99,101,103,105,107Tc is presented as well. The existence of this intruder band has been argued previously in 95,97,99,101,103Tc isotopes (partially populated) and fully observed and confirmed in 105Tc. It will be shown that changes in deformation and subsequently the position of the Fermi level, vis a vis the 1/2+[431] intruder orbital originating from the π(d5/2, g7/2) subshells, predominantly affect these systematic changes. All four interpreted experimental rotational bands are naturally predicted by the rotational model as bands build on states of good Ω originating from the 5/2+[422], 5/2–[303], 3/2–[301], and 1/2+[431] orbitals near the Fermi level in deformed 105Tc (strong coupling). Further experimental investigation about missing data are needed for those observed in low lying states in both 105Tc and 103Tc to confirm the presence of the 1/2–[301] rotational band that is well defined in lighter 95,97,99,101Tc isotopes.
10Be ages of flood deposits west of Lake Nipigon, Ontario: evidence for eastward meltwater drainage during the early Holocene Epoch
(Canadian Science Publishing, 2016-01-04) Kelly, Meredith A.; Fisher, Timothy G.; Lowell, Thomas V.; Barnett, Peter J.; Schwartz, Roseanne
The Nipigon channels, located to the west and northwest of Lake Nipigon, Ontario, are thought to have enabled the eastward drainage of meltwater from glacial Lake Agassiz during the last deglaciation. Here we present the first direct ages of flood deposits in two of these channels using 10Be surface exposure dating. Five 10Be ages of a coarse-grained deposit near the Roaring River in the Kaiashk channel complex indicate deglaciation and cessation of water flow by ~11,070±430 yr. To test for inherited nuclides in boulder samples, we also measured the 10Be concentrations of the undersides of two boulders at the Roaring River site. Five 10Be ages of boulders atop a large bedform near Mundell Lake in the Pillar channel complex indicate deglaciation and cessation of water flow by ~10,770±240 yr. Two 10Be ages of nearby bedrock are slightly younger (10,340±260 and 9,860±270 yr). The 10Be ages from the two sites are statistically indistinguishable and indicate that Laurentide Ice Sheet recession occurred rapidly in the region. We used clast diameters and channel dimensions at the Mundell Lake site to estimate paleo-discharge and evaluate the possibility that meltwater drainage influenced climate conditions. We estimate a large maximum discharge of 119,000–159,000 m3s-1 at the site. However, the timing of meltwater discharge at both Roaring River and Mundell Lake is not contemporaneous with abrupt climate events.
12 days of altitude exposure at 1800m does not increase resting metabolic rate in elite rowers.
(Canadian Science Publishing, 2017-02-16) Woods, Amy L; Garvican-Lewis, Laura A; Rice, Anthony; Thompson, Kevin Grant
Four elite rowers completed a twelve-day altitude training camp living at 1800m, and training at 1800m and 915m, to assess changes in resting metabolic rate (RMR). RMR and body composition were assessed PRE and POST-camp. Downward trends in RMR and body composition were observed post-altitude: absolute RMR (percent change: -5.2%), relative RMR (-4.6%), body mass (-1.2%), and fat mass (-4.1%), likely related to the hypoxic stimulus and an imbalance between training load and energy intake.
A 1300 year reconstruction of paleofloods using oxbow lake sediments in temperate southwestern Québec, Canada
(Canadian Science Publishing, 2016-01-10) Oliva, Frank; Viau, Andre E.; Bjornson, Jean; Desrochers, Nicolas M; Bonneau, Marc-André
The study of paleofloods provides important information on past flood frequency and intensity for regions where there is a paucity of records, it therefore extends our knowledge of flood occurrence beyond the historical record. Many paleoflood reconstructions come from the arid dry climate of southwestern USA and from Europe with few studies being conducted in temperate climates of North America. This study uses sediment cores from oxbow lakes to reconstruct past flood events in a temperate region. Cores extracted from two oxbow lakes along the Désert River in southwestern Québec, Canada were analyzed for magnetic susceptibility, loss-on-ignition, grain-size and were radiocarbon dated (14C). Using a combination of magnetic susceptibility variations, along with changes in grain-size and organic material content, 5 floods were identified within the 220 cm core (1300 years) from the North oxbow lake, and six floods in the 118 cm core (600 years) from the South oxbow lake. This study provides evidence to support the use of oxbow lakes in temperate regions as a proxy of past floods, thus helping us understand hydroclimatic changes at regional scales. Data that spans a longer period of time and in different environments is key to increase flood modelling accuracy to improve mitigation strategies under a changing climate.
1980s population-specific compositions of two related anadromous shad species during the oceanic phase determined by microchemistry of archived otoliths
(Canadian Science Publishing, 2019-06-04) Nachón, David José; Bareille, Gilles; Drouineau, Hilaire; Tabouret, Hélène; Taverny, Catherine; Boisneau, Catherine; Berail, Sylvain; Pécheyran, Christophe; Claverie, Fanny; Daverat, Françoise
The specific stock composition and dispersion of anadromous fish species aggregations in the marine environment are poorly known, while they can play a major role in the metapopulation dynamics. Otolith microchemistry has proven to be a powerful tool to address natal origins of anadromous fish. We used archived otolith microchemistry to investigate the population-specific composition of subadult European shads (Alosa alosa and Alosa fallax) in the ocean during the 1980s. The allocation of natal origin was addressed relying on contemporary water and juveniles’ signatures within a Bayesian model. A great discrimination of natal origin was obtained at the Biscay Gulf scale. However, the discrimination of 1980s natal origin for the southern rivers with similar geology based on 2013 water and juveniles’ baselines was doubtful. Our results showed that the most abundant southern populations were dominant, suggesting that population-specific composition was related to population relative abundance. The dispersion in the marine environment was plastic; alternatively, shads were found large distances away from their natal rivers, while others remained in the vicinity of their natal river plume.
2013 Colloquium of the Canadian Geotechnical Society: Geotechnical and Geoenvironmental behaviour of High Density Tailings
(Canadian Science Publishing, 2016-06-29) Simms, Paul
The breaching of containment of conventionally deposited mine tailings impoundments, and the consequent release of tailings flows with long run-outs, unfortunately remains not uncommon and often has devastating ecological and economic consequences, occasionally including the loss of human life. Rather than the breaching of containment itself, which can result from a number of causes (poor control of the phreatic surface, unrecognized dam foundation issues), the contributing factor to the severe consequences of dam breach is the very low density and strength and / or susceptibility of the tailings to liquefy or soften under loading, combined with the driving weight of the ponded water, which allows for significant run-outs (in some cases 10â s of kilometres) to occur. Hence the motivation for alternative technologies that dewater tailings before deposition to the point where reliance on containment is minimized or eliminated. In this paper, these technologies are referred to as High Density tailings, which includes any technology that at least produces non-segregating tailings that will form a sloped stack when deposited, including thickened, paste, and filtered tailings. The paper explores a number of issues related to high density tailings, including shear behaviour, dewatering behaviour, acid generation, and surface deposition rheology. The paper concludes with some discussion on what are the limitations on this technology holding back its wider adoption, and how these limitations might be overcome.
2019 Canadian Geotechnical Colloquium: Mitigating a fatal flaw in modern geomechanics: understanding uncertainty, applying model calibration, and defying the hubris in numerical modelling
(Canadian Science Publishing, 2021-05-19) Kalenchuk, Kathy
This paper has been written to achieve two objectives. The first objective is to provide a discussion of the practical limitations of numerical modelling in the field of geomechanical engineering. Too many discussions of numerical methods in geomechanical engineering are centered on the impressive ability of numerical tools to conduct complex and sophisticated analyses with relative ease and efficiency. Practitioners need to have grounded conversations of numerical modelling regarding the reality that geomechanical designs are often data limited with high degrees of uncertainty. When data limits and uncertainty are overlooked, geomechanical engineers are at risk of introducing unforeseen fatal flaws into engineering design. The second objective is to provide ‘how to’ guidelines for model calibration using a variety of data types to qualify and quantify ground reaction. Model calibration is truly the only means to reduce numerical uncertainties. Formal training in numerical modelling is often focused on software utilization and computational methods; however, there are few opportunities for formal training on how to calibrate a model for practical engineering applications. This paper provides guidelines for calibration methods and procedures.
A 2169 Ma U-Pb baddeleyite age for the Otish Gabbro, Quebec: Implications for correlation of Proterozoic magmatic events and sedimentary sequences in the eastern Superior Province
(Canadian Science Publishing, 2015-11-25) Hamilton, Michael A.; Buchan, Kenneth L.
Otish Gabbro sills intrude sedimentary rocks in the Otish Basin of the southeastern Superior Province. Here, deposition of Otish Supergroup sediments had previously been thought to be older than K-Ar and Sm-Nd ages of ca. 1750-1710 Ma for Otish Gabbro sills, and younger than ca. 2515-2500 Ma U-Pb ages of underlying Mistassini dykes. However, a much older U-Pb baddeleyite age of 2169.0 ± 1.4 Ma is presented here for an Otish sill, indicating that they are coeval with, and likely genetically related to, the giant 2172-2167 Ma Biscotasing dyke swarm to the southwest and (or) the Cramolet sills and Payne River dykes to the north. The new date also indicates that the age of the Otish Supergroup falls between ca. 2515 Ma and ca. 2169 Ma, only a little different from the ca. 2450-2217 Ma bracket for the Huronian Supergroup of the Southern Province, and is consistent with both supergroups spanning the oxy-atmo inversion. The Otish Supergroup could also be coeval with the Sakami Formation to the north, but is likely older than the Richmond Gulf Group on the east coast of Hudson Bay. Early paleomagnetic study of Otish sills yielded a remanence ~20° from that expected for Biscotasing-aged intrusions. This may indicate that too few distinct sills were studied to average out paleosecular variation, that demagnetization techniques failed to fully remove unstable magnetization components, or that the remanence is a stable secondary overprint, perhaps acquired during a fluid event related to uranium mineralization at ca. 1720 Ma.
2D and 3D Numerical Modelling of Exposed Steel Base Plate Connections under Cyclic Loading
(Canadian Science Publishing, 2022-03-31) Singh, Gursarbjot; Woods, Joshua
The degree of fixity at the base of steel gravity columns with exposed base plate connections is often assumed in analysis and design. However, past experiments have shown these connections do provide lateral stiffness and strength that could contribute to the load carrying capacity of a structure. The goal of this study is to develop a numerical modelling approach for exposed steel base plate connections that can capture their nonlinear cyclic behaviour, including their stiffness, strength, and energy dissipation capacity. Two modelling approaches are proposed, one that is suitable for detailed study of connection behaviour and another comparatively simple approach that can be used in nonlinear time-history analysis of a structure. Results from the two methodologies are compared with experimental data from the literature and the results show that both approaches can capture the nonlinear cyclic response of the studied connections. Limitations of the proposed modelling approach are also discussed.
3-Bromopyruvate potentiates TRAIL-induced apoptosis in human colon cancer cells through a reactive oxygen species- and caspase-dependent mitochondrial pathway
(Canadian Science Publishing, 2019-07-17) Abbaszadeh, Hassan; Valizadeh, Armita; Mahdavinia, Masoud; Teimoori, Ali; Pipelzadeh, Mohammad Hassan; Zeidooni, Leila; Alboghobeish, Soheila
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising anticancer cytokine with minimal toxicity towards normal cells. Nevertheless, most primary cancers are often intrinsically TRAIL-resistant or can acquire resistance after TRAIL therapy. This study aimed to investigate the inhibitory effect of co-treatment of 3-Bromopyruvate (3-BP) as a potent anticancer agent with TRAIL on colon cancer cells (HT-29). The results of present study indicated that combined treatment with 3-BP and TRAIL inhibited the proliferation of HT-29 cells to a greater extent (88.4%) compared with 3-BP (54%) or TRAIL (11%) treatment alone. In contrast, the combination of 3-BP and TRAIL had no significant inhibitory effect on the proliferation of normal cells (HEK-293) (8.4%). At a cellular mechanistic level, the present study showed that 3-BP sensitized human colon cancer cells to TRAIL-induced apoptosis via ROS generation, upregulation of Bax, downregulation of Bcl-2 and survivin, release of cytochrome c into the cytosol and activation of caspase3. In normal cells, 3-BP, TRAIL or combination of both had no significant effect on the ROS levels, release of cytochrome c and caspase3 activity. Therefore, the combination of 3-BP and TRAIL can be a promising therapeutic strategy for treatment of colon cancer.
The 3-I Framework: a framework for developing public policies regarding pharmacogenomics (PGx) testing in Canada
(Canadian Science Publishing, 2015-11-10) Bashir, Naazish Sultana; Ungar, Wendy J.
The 3-I framework of analyzing the “ideas”, “interests”, and “institutions” around a topic has been used by political scientists to guide public policy development. In Canada, there is a lack of policy governing pharmacogenomics (PGx) testing compared to other developed nations. The goal of this study was to use the 3-I framework, a policy development tool, and apply it to pharmacogenomics testing to identify and analyze areas where current policy is limited and challenges exist in bringing pharmacogenomics testing into wide-spread clinical practice in Canada. A scoping review of the literature was conducted to determine the extent and challenges of PGx policy implementation at federal and provincial levels. Based on the 3-I analysis, contentious ideas related to PGx are (i) genetic discrimination, (ii) informed consent, (iii) the lack of knowledge about PGx in health care, (iv) the value of PGx testing, (v) the roles of health care workers in the coordination of PGx services and (vi) confidentiality and privacy. The 3-I framework is a useful tool for policy makers, and applying it to pharmacogenomics policy development is a new approach in Canadian genomics. Policy makers at every organizational level can use this analysis to help develop targeted PGx policies.
3D ergonomics-based motion-level productivity analysis for intelligent manufacturing in industrialized construction
(Canadian Science Publishing, 2022-08-08) Wang, Jingwen; Mohamed, Yomna; Han, Sang Hyeok; Li, Xinming; Al-Hussein, Mohamed
In industrialized construction, accurate estimations of labour productivity and associated cycle times of repetitive operations are crucial for reliable production planning and scheduling. However, the reliability of the standardized productivity and cycle time analyses is hindered by their dependence on various factors that change with the increasing complexity of the working environment, as well as by inherent challenges involved in acquiring accurate measurements. Thus, this study proposes an automated 3D ergonomics-based motion-level productivity analysis method for intelligent manufacturing in industrialized construction that combines an existing predetermined motion time system with ergonomic risk assessments and 3D modelling techniques. The actual and simulated cycle times and ergonomic risks of preliminary cases in the experiment are analyzed to demonstrate the feasibility and reliability of the proposed method. The proposed method can be implemented to improve occupational safety, increase the reliability of planning and scheduling, and boost the overall productivity of industrialized construction.
3D finite element analysis of the behaviour of cross passage between cast-iron tunnels
(Canadian Science Publishing, 2015-12-03) Li, Zili; Soga, Kenichi; Wright, Peter
The behaviour of cast-iron cross passages in London Underground was investigated using 3D finite element models. Unlike the behaviour of a full tunnel ring, the structural integrity of a tunnel cross passage opening relies on the support from adjacent linings. In clayey soils, the opening may deform further as the soil stiffness changes from undrained to drained conditions. The degradation of circumferential bolts and trackbed may also lead to further tunnel movement. A parametric study was conducted to examine the influence of soil stiffness and structural components (e.g. bolts and lintel) on the structural integrity of a tunnel opening. Results show that a lintel effectively transfers the load above the opening to the adjacent linings, and its distortion affects tunnel deformation significantly. If a lintel is not present, both bolts and friction between tunnel segments provide shear resistance to the lining deformation at the tunnel opening against soil loading. The results are compared to the field observations made at a critical cross passage in one of the London Underground tunnels. The findings contributed to identifying the critical deformation mechanisms of cast-iron tunnel cross passages, which can be useful during inspection of such structures.
3D gravity modelling applied to the exploration of uranium unconformity-related basement hosted deposits: the Contact prospect case study, Kiggavik, NE Thelon region (Nunavut, Canada)
(Canadian Science Publishing, 2017-05-04) Roy, Régis; Benedicto, Antonio; Grare, Alexis; Béhaegel, Mickaël; Richard, Yoann; Harrison, Grant
In unconformity-related uranium deposits mineralization is associated with hydrothermal clay-rich alteration haloes that decrease the density of the host rock. In the Kiggavik Uranium project, located in the eastern Thelon Basin, Nunavut (Canada), basement-hosted shallow deposits were discovered by drilling geophysical anomalies in the 1970s. In 2014, gravity data was inverted for the first time using the Geosoft VOXI Earth ModellingTM system to generate 3D models to assist exploration in Contact, the most recent discovery at Kiggavik. A 3D unconstrained inversion model was calculated before drilling and a model constrained with petrophysical data model was computed after drilling. The unconstrained inversion provided a first approximation of the geometry and depth of a low density body and helped to collar the discovery holes of the Contact mineralization. The constrained inversion was computed using density values measured on 315 core samples collected from the 21 drill-holes completed between 2014 and 2015. The constrained modelling highlights three shallower and smaller low density bodies that match the geological interpretation and refines the footprint of the gravity anomalies in relation to the current understanding of the deposit. The 3D inversion of gravity data is a valuable tool to guide geologists in exploration of shallow basement-hosted uranium deposits associated with alteration haloes and to assess the deposit gravity geometry.

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