Vulvar ulcer as a presentation of systemic langerhans cell histiocytosis

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Date

2011-10-06

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Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)

Abstract

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We report a 38-year-old housewife with systemic Langerhans cell histiocytosis (LCH) presenting as a chronic vulvar and peri-anal ulcer. She had systemic involvement in the form of diabetes insipidus and bone "hot-spots". She responded favorably to etoposide, 6-mercaptopurine, and systemic steroids, and has been in remission since 10 years. Chronic vulvar ulcers not responding to routine therapy should not be neglected and need to be biopsied repeatedly to come to a specific diagnosis. The vulvar ulcer in our case provided a vital clue to a systemic LCH, with a successful outcome.

Keywords

etoposide, diabetes insipidus, vulvar ulcer, Langerhans cell histiocytosis

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http://hdl.handle.net/1807/48810
 http://www.bioline.org.br/abstract?id=dv11048
 http://www.bioline.org.br/dv
 http://www.ijdvl.com

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Indian Journal of Dermatology, Venereology and Leprology
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