Effect of Albizia julibrissin on Growth and Brain Monoamine Neurotransmitters in Chronic-Stressed Rats
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Kunming Institute of Zoology, Chinese Academy of Sciences
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The study was conducted to investigate the effects of Albizia
julibrissin on growth and brain monoamine neurotransmitters in
chronic-stressed rats. Fifteen rats were divided into three groups
including the control group, stressed group and Albizia julibrissin
treated group. The rats in both the stressed and treated groups were
stressed for seven days, and the rats in the treated group were fed
with Albizia julibrissin by gavage administration for 10 days after
stress. At the conclusion of the experiment, brain tissues were
collected from the three groups to analyze the content of homovanillic
acid (HVA), norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine
(5-HT). The indices above were determined by high pressure liquid
chromatogram (HPLC). The results showed that the daily growth in mass
of rats in the stressed group significantly decreased compared with the
control group (P=0.011), while the Albizia julibrissin treated group
had a higher growth than that of the stressed group (P=0.002). The HVA
levels of the hippocampus, striatum and prefrontal lobes in the
stressed group were not significantly different from the control group,
though there was a tendency for higher levels in the stressed group.
The stress had no significant effects on levels of NE, DA and 5-HT. The
levels of HVA and DA in the hippocampus in the Albizia julibrissin
treated group were significantly higher than those of the stressed
group, while DA and 5-HT of the prefrontal lobes and 5-HT of the
striatum were significantly lower than the stressed group. These
results suggest that Albizia julibrissin alleviates the growth
inhibition caused by stress, and regulates the levels of monoamine
neurotransmitters of the brain in stressed rats.
Keywords
Ratp; Stress; Albizia julibrissin; Growth; Monoamine neurotransmitter
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