Blood Pressure Reducing Effect of Bitter Kola ( Garcinia kola , Heckel) in Wistar Rats
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Ibadan Biomedical Communications Group
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In this study the effect of Garcinia kola (GK) on blood pressure was
investigated. Albino wistar rats were divided into three groups. Groups
A rats had normal rat chow and water ad-libitum while groups B and C
rats had Garcinia kola diet of 10% w/w and 15% w/w respectively, their
blood pressures were monitored weekly for a period of 6 weeks.
Secondly, inbred wistar rats weighing on the average 185g were
anaestezized with thiopentone sodium 100mg/kg body weight (b.wt)
intraperitoneally and prepared for injection and for blood pressure
measurements on a recording device (Ugo Basile Itlay). Significant
reduction in blood pressure (P <0.05) was observed in rats given
GK-enriched diets, in the third week. During preliminary investigations
it was observed that 5.0mg/kg b.wt dose of extract was lethal after 6
minutes, while 3.0mg/kg b.wt of the extract was tolerated for upwards
of four hours. Based on these findings, graded doses of the extract.
(0.5 – 3.0mg/kg) were used and these doses produced statistically
significiant (P <0.05) fall in mean arterial pressure and also
significant (P <0.05) increase in heart rate. Cholinergic blockade
produced no significant attenuation on the effect of extract. However
there was a significant (P <0.05) attenuation to extract effect
after Histaminergic blockade. This study shows that Garcinia kola
contains in its alcohol extract, a vasoactive substance that has a
blood pressure reducing effect.
Keywords
Heart rate, Vasoactive, Garcinia kola, blood pressure
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