The ontogeny of P-glycoprotein in the developing human blood-brain barrier: implication for opioid toxicity in neonates

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Date

2015-02-18

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Publisher

Nature Publishing Group

Abstract

Neonates have been shown to have a heightened sensitivity to the central depressive effects of opioids compared to older infants and adults. The limited development of P-glycoprotein (P-gp) may limit the ability of the neonate to efflux morphine from the brain back to the systemic circulation. The objective of the study was to determine the ontogeny of P-gp in the human brain.

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Citation

Lam, Jessica, et al. "The ontogeny of P-glycoprotein in the developing human blood–brain barrier: implication for opioid toxicity in neonates." Pediatric research 78.4 (2015): 417.

URI

http://hdl.handle.net/1807/82545

DOI

10.1038/pr.2015.119

ISSN

0031-3998

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Attribution 4.0 International

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http://creativecommons.org/licenses/by/4.0/

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Department of Physiology
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