Interrupting prolonged sitting with repeated chair stands or short walks reduces postprandial insulinemia in healthy adult

dc.contributor.authorGillen, Jenna B.
dc.contributor.authorEstafanos, Stephanie
dc.contributor.authorWilliamson, Eric
dc.contributor.authorHodson, Nathan
dc.contributor.authorMalowany, Julia M.
dc.contributor.authorKumbhare, Dinesh
dc.contributor.authorMoore, Daniel R.
dc.date.accessioned2021-09-30T21:15:18Z
dc.date.available2021-09-30T21:15:18Z
dc.date.issued2021-01-14
dc.descriptionThis is an accepted manuscripten_US
dc.description.abstractWe determined if interrupting prolonged sitting with practical “activity snacks” could reduce postprandial glycemia and insulinemia in healthy adults. Fourteen participants (7 males, 7 females; 24 ± 5 yr; 25 ± 5 kg/m2; 40 ± 8 mL/kg/min; 7,033 ± 2,288 steps/day) completed three 7.5-h trials in a randomized order consisting of uninterrupted sitting (SIT), sitting with intermittent (every 30 min) walking (WALK; 2 min at 3.1 mph), or sitting with intermittent squats (SQUAT; 15 chair stands with calf raise). Mixed-macronutrient liquid meals provided 20% (“breakfast”) and 30% (“lunch”) of daily energy needs to mimic Western meal patterns. Blood samples were obtained for analysis of postprandial plasma glucose and insulin concentrations, and skeletal muscle biopsy samples were collected to measure markers of contraction- and insulin-mediated glucose uptake signaling. Postprandial glucose and insulin did not differ across conditions following breakfast. After lunch, peak insulin concentration was lower in SQUAT (52 ± 27, P < 0.01) and WALK (62 ± 35, P < 0.05) compared with SIT (79 ± 43 μIU/mL). The insulin incremental area under the curve (iAUC) 1 h following lunch was 37 and 29% lower in SQUAT (P < 0.01) and WALK (P < 0.05) compared with SIT, respectively; however, 3-h insulin iAUC was reduced in SQUAT only (24% vs. SIT, P < 0.05). The 3-h insulin:glucose iAUC was reduced following lunch in both SQUAT (30%) and WALK (23%) compared with SIT (P < 0.05). Phosphorylation of AKTThr308, AKTSer473, and AS160Ser318 was not different between conditions (P > 0.05). Interrupting prolonged sitting with short walks or repeated chair stands reduces postprandial insulinemia in healthy adults. Our results may have implications for mitigating cardiometabolic disease risk in adults who engage in periods of prolonged sitting.en_US
dc.description.sponsorshipThis study was supported in part by an American College of Sports Medicine Research Endowment and NSERC Discovery grant to JBG. N. Hodson is a postdoctoral research fellow funded through the Mitacs Accelerate Program (No. IT15730). JBG was supported by a CIHR postdoctoral fellowship during study design and early phases of data collection.en_US
dc.identifier.citationGillen, J. B., Estafanos, S., Williamson, E., Hodson, N., Malowany, J. M., Kumbhare, D., & Moore, D. R. (2021). Interrupting prolonged sitting with repeated chair stands or short walks reduces postprandial insulinemia in healthy adults. Journal of applied physiology (Bethesda, Md. : 1985), 130(1), 104–113.en_US
dc.identifier.doi10.1152/japplphysiol.00796.2020en_US
dc.identifier.issn8750-7587en_US
dc.identifier.urihttp://hdl.handle.net/1807/107598
dc.language.isoen_caen_US
dc.publication.journalJournal of Applied Physiologyen_US
dc.publisherAmerican Physiological Societyen_US
dc.subjectsedentary behaviouren_US
dc.subjectphysical activityen_US
dc.subjectglucoseen_US
dc.subjectinsulinen_US
dc.subjectskeletal muscleen_US
dc.titleInterrupting prolonged sitting with repeated chair stands or short walks reduces postprandial insulinemia in healthy adulten_US
dc.typeArticle Post-Printen_US

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