Clinicoepidemiologic features of chronic urticaria in patients having positive versus negative autologous serum skin test: A study of 100 Indian patients

dc.contributor.authorVohra, Surbhien_US
dc.contributor.authorSharma, Nand Lal.en_US
dc.contributor.authorMahajan, Vikram K.en_US
dc.contributor.authorShanker, Vinayen_US
dc.date.accessioned2014-05-06T22:32:02Z
dc.date.available2014-05-06T22:32:02Z
dc.date.issued2011-10-06en_US
dc.descriptionBackground: Chronic urticaria patients who demonstrate autoantibodies against the high-affinity receptor of IgE (FceRI) or IgE itself tend to have a high itch and wheal score, and systemic symptoms may have a significant bearing on their management in terms of super pharmacologic doses of antihistamines needed or use of immunomodulators. Most studies have used histamine release assays rather than autologous serum skin tests (ASSTs) for correlating urticaria severity and histamine releasing activity. Methods: An ASST was performed in 100 (M:F, 31:69) chronic urticaria patients aged between 14 and 63 (mean, 32.69 ± 13) years with an objective to study the clinicoepidemiologic features like age, sex, age of onset and duration, frequency and distribution of wheals, urticaria severity, angioedema and systemic manifestations in ASST-positive and ASST-negative patients. Results: ASST was positive in 46% of the patients and negative in 54% of the patients, respectively. Both groups showed no statistically significant difference for epidemiological details. However, the ASST-positive patients had a higher mean urticaria activity score, frequent involvement of more body sites, particularly palms and soles, presence of throat angioedema and general constitutional, respiratory or gastrointestinal symptoms in comparison with the ASST-negative patients. Conclusions: Apparently, ASST-positive patients have more severe clinical manifestations of chronic urticaria. The knowledge will be useful for the treating dermatologists and patients alike in view of its therapeutic implications.en_US
dc.identifier.urihttp://hdl.handle.net/1807/48806
dc.identifier.urihttp://www.bioline.org.br/abstract?id=dv11044en_US
dc.identifier.urihttp://www.bioline.org.br/dven_US
dc.identifier.urihttp://www.ijdvl.comen_US
dc.languageenen_US
dc.locationOrigin of publication: Indiaen_US
dc.publication.journalIndian Journal of Dermatology, Venereology and Leprology (ISSN: 0378-6323) Vol 77 Num 2en_US
dc.publisherMedknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)en_US
dc.rights.holderCopyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.en_US
dc.subjectautologous serum skin testen_US
dc.subjectanti-IgE autoantibodiesen_US
dc.subjectangioedemaen_US
dc.subjectUrticariaen_US
dc.titleClinicoepidemiologic features of chronic urticaria in patients having positive versus negative autologous serum skin test: A study of 100 Indian patientsen_US
dc.typeArticleen_US

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