Clinicoepidemiologic features of chronic urticaria in patients having positive versus negative autologous serum skin test: A study of 100 Indian patients
Date
2011-10-06
Journal Title
Journal ISSN
Volume Title
Publisher
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
Abstract
Description
Background: Chronic urticaria patients who demonstrate autoantibodies
against the high-affinity receptor of IgE (FceRI) or IgE itself tend to
have a high itch and wheal score, and systemic symptoms may have a
significant bearing on their management in terms of super pharmacologic
doses of antihistamines needed or use of immunomodulators. Most studies
have used histamine release assays rather than autologous serum skin
tests (ASSTs) for correlating urticaria severity and histamine
releasing activity. Methods: An ASST was performed in 100 (M:F, 31:69)
chronic urticaria patients aged between 14 and 63 (mean, 32.69 ±
13) years with an objective to study the clinicoepidemiologic features
like age, sex, age of onset and duration, frequency and distribution of
wheals, urticaria severity, angioedema and systemic manifestations in
ASST-positive and ASST-negative patients. Results: ASST was positive in
46% of the patients and negative in 54% of the patients, respectively.
Both groups showed no statistically significant difference for
epidemiological details. However, the ASST-positive patients had a
higher mean urticaria activity score, frequent involvement of more body
sites, particularly palms and soles, presence of throat angioedema and
general constitutional, respiratory or gastrointestinal symptoms in
comparison with the ASST-negative patients. Conclusions: Apparently,
ASST-positive patients have more severe clinical manifestations of
chronic urticaria. The knowledge will be useful for the treating
dermatologists and patients alike in view of its therapeutic
implications.
Keywords
autologous serum skin
test, anti-IgE autoantibodies, angioedema, Urticaria
Citation
DOI
ISSN
Creative Commons
Creative Commons URI
Items in TSpace are protected by copyright, with all rights reserved, unless otherwise indicated.