Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice

dc.contributor.authorMAO, Yuen_US
dc.contributor.authorYANG, Shang-Chuanen_US
dc.contributor.authorLIU, Changen_US
dc.contributor.authorMA, Yuan-Yeen_US
dc.contributor.authorHU, Xin-Tianen_US
dc.date.accessioned2014-05-09T20:24:02Z
dc.date.available2014-05-09T20:24:02Z
dc.date.issued2012-01-15en_US
dc.descriptionTo interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the β-adrenergic receptor (β-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. However, the relationship between PRO and the acquisition or retrieval of morphine-cue memory is not clear.This study examined the effects of PRO on the acquisition and retrieval of memories in morphine-induced conditioned place preference (CPP) mice model. We found that during memory acquisition period, PRO had no effects on the expression and extinction of morphine-CPP, which suggests that the β-AR was irrelevant to the CPP memory acqusition. However, during memoery retrival period, although PRO did not affect the expression of CPP, but it delayed the occurrence of CPP extinction, which indicates that PRO has an inhibit effect on CPP memery extinction, and β-AR plays an important role in modulating the extinction of morphine-CPP. Our study further improved the relationship between drug addiction and β-AR, and proposed a new theory to help developing potential therapy to cure addiction and other neuropsychiatric disorders.en_US
dc.identifier.urihttp://hdl.handle.net/1807/64725
dc.identifier.urihttp://www.bioline.org.br/abstract?id=zr11097en_US
dc.identifier.urihttp://www.bioline.org.br/zren_US
dc.identifier.urihttp://www.zoores.ac.cn/en_US
dc.languagecnen_US
dc.locationOrigin of publication: Chinaen_US
dc.publication.journalZoological Research (ISSN: 0254-5853) Vol 32 Num 6en_US
dc.publisherKunming Institute of Zoology, Chinese Academy of Sciencesen_US
dc.rights.holderCopyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciencesen_US
dc.subjectConditioned place preferenceen_US
dc.subjectOpioiden_US
dc.subjectAcquisition Retrievalen_US
dc.subjectMemoryen_US
dc.subjectβ-adrenergic receptoren_US
dc.titleEffects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR miceen_US
dc.typeArticleen_US

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