Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice
Date
2012-01-15
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Kunming Institute of Zoology, Chinese Academy of Sciences
Abstract
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To interfere with the drug-cue memory processes of addicts such as
reconsolidation by the administration of the β-adrenergic receptor
(β-AR) of norepinephrine (NE) antagonist propranolol (PRO) has
become a potential therapy in the future to decrease or inhibit
relapse. However, the relationship between PRO and the acquisition or
retrieval of morphine-cue memory is not clear.This study examined the
effects of PRO on the acquisition and retrieval of memories in
morphine-induced conditioned place preference (CPP) mice model. We
found that during memory acquisition period, PRO had no effects on the
expression and extinction of morphine-CPP, which suggests that the
β-AR was irrelevant to the CPP memory acqusition. However, during
memoery retrival period, although PRO did not affect the expression of
CPP, but it delayed the occurrence of CPP extinction, which indicates
that PRO has an inhibit effect on CPP memery extinction, and β-AR
plays an important role in modulating the extinction of morphine-CPP.
Our study further improved the relationship between drug addiction and
β-AR, and proposed a new theory to help developing potential
therapy to cure addiction and other neuropsychiatric disorders.
Keywords
Conditioned place preference, Opioid, Acquisition Retrieval, Memory, β-adrenergic receptor
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