Biocompatibility evaluation of an antibiotic paste after pulpotomy in dogs
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Piracicaba Dental School - UNICAMP
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The purpose of this study was to evaluate by histological analysis, the
biocompatibility of an antibiotic paste following treatment of
pulpotomies in dogs. Four male adult dogs were used and their
mandibular and maxilar premolars and molars (PM3; PM4; M1; PM4; M1) of
both sides were submitted to pulpotomies. The antibiotic paste (CTZ)
was prepared with chloramphenicol, tetracycline, zinc oxide and
eugenol. After 6, 8, 9 and 10 months post-pulpotomy the dogs were
sacrificed. Histological analysis of the teeth revealed an intense
inflammatory process in the coronal pulp at 6 months after pulpotomy,
with inflammatory cells dispersed throughout the entire apical region
in this period. This process became partially reduced at 8 and 9 months
after pulpotomy, and totally disappeared by the end of the experiment,
at 10 months. In conclusion, the endodontic treatment with this
antibiotic paste seemed to be biocompatible under the present
experimental conditions. However, further clinical studies are
necessary to assure that this paste is safe for use in pulpotomies in
children.
Keywords
biocompatibility tests, antibiotic paste, pulpotomy, pulp therapy
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