Practitioners section-Cytochrome P450 enzyme isoforms and their therapeutic implications: An update
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Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
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Clinicians should be cognizant of potential drug drug interactions and
become familiar with the substrates, inhibitors and inducers of the
common enzymatic pathways responsible for drug metabolism. Our
knowledge of and ability to predict drug interactions have improved
with growing understanding of substrates, inhibitors and inducers of
cytochrome P450 (CYP-450) isoenzymes. These isoenzymes are a major
determinant of the pharmacokinetic behavior of numerous drugs. In
addition to inhibition and induction, microsomal drug metabolism is
affected by genetic polymorphisms, age, nutrition, hepatic disease and
endogenous chemicals. Prescribing physicians by understanding the
unique characteristics of these isoenymes may better anticipate and
manage drug drug interactions.
Keywords
enzyme inhibitor, drug interaction, Cytochrome P450
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