Role of Specific Synaptic Plasticity Interfering Peptides in the Expression of Morphine Induced Conditioned Place Preference in Mice

dc.contributor.authorWu, Kunen_US
dc.contributor.authorXu, Linen_US
dc.contributor.authorHuang, Jing-feien_US
dc.date.accessioned2014-05-09T20:23:08Z
dc.date.available2014-05-09T20:23:08Z
dc.date.issued2010-06-15en_US
dc.descriptionLearned association between context and drug abuse is essential for the drug conditioned place preference (CPP), which is an animal model widely used to measure drug reward. Synaptic plasticity, in the form of long-term potentiation (LTP) and depression (LTD), is regarded as a proposed cellular substrate of learning and memory. However, the exact role of LTP/LTD in addiction is not known yet. Therefore, by bioinformatics we designed peptides aiming to interfere with LTP and LTD respectively, to study their individual role in the expression of morphine CPP. We found that the interfering peptide Pep-A2 can specifically block hippocampal LTP in CA1 region, whereas Pep-A3 can block LTD in this region. Treatment of either of their cell penetrating forms (Tat-A2 or Tat-A3) before test can block the expression of Morphine CPP in mice. These results suggested that both LTP and LTD are required in the drug-associated learning and memoryen_US
dc.identifier.urihttp://hdl.handle.net/1807/64331
dc.identifier.urihttp://www.bioline.org.br/abstract?id=zr09058en_US
dc.identifier.urihttp://www.bioline.org.br/zren_US
dc.identifier.urihttp://www.zoores.ac.cn/en_US
dc.languageenen_US
dc.locationOrigin of publication: Chinaen_US
dc.publication.journalZoological Research (ISSN: 0254-5853) Vol 30 Num 4en_US
dc.publisherKunming Institute of Zoology, Chinese Academy of Sciencesen_US
dc.rights.holderCopyright 2009 Kunming Institute of Zoology, the Chinese Academy of Sciencesen_US
dc.subjectLTP; LTD; Reward; CPPen_US
dc.titleRole of Specific Synaptic Plasticity Interfering Peptides in the Expression of Morphine Induced Conditioned Place Preference in Miceen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
zr09058.pdf
Size:
410.56 KB
Format:
Adobe Portable Document Format