The role of CD36 in the pathophysiology of malaria: validation of a murine model and design of a clinical study

dc.contributor.authorKatz, Kevin
dc.date.accessioned2022-06-21T20:00:08Z
dc.date.available2022-06-21T20:00:08Z
dc.date.issued2004
dc.description.abstractCD36 has been shown to play a central role in phagocytic clearance of Plasmodium falciparum malaria, in cytoadherence of parasitized erythrocytes to endothelium and in maintaining a balanced cytokines state. Significant progress has been made in elucidating C1336-malaria interactions in vitro but an animal model of Plasmodium falciparum does not exist. We have developed and validated a murine malaria model for examining the in vivo role of CD36 in the pathophysiology of severe malaria infection. Accumulating evidence suggests that upregulation of CD36 may be beneficial in P. falciparum infections and may increase phagocytic clearance of P. falciparum malaria, modulate deleterious inflammatory responses to infection and decrease sequestration of malaria parasites in vital organs. This strategy may therefore represent a novel immunomodulatory treatment approach for severe P. falciparum malaria. We have designed a pilot human study to address this issue.
dc.description.degreeM.Sc.
dc.identifier.isbn0612954595
dc.identifier.isbn9780612954595
dc.identifier.otherhttp://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95137=F
dc.identifier.otherhttp://gateway.proquest.com/openurl?url_ver=Z39.88-2004=info:ofi/fmt:kev:mtx:dissertation=xri:pqm=xri:pqdiss:MQ95459
dc.identifier.urihttp://hdl.handle.net/1807/121087
dc.titleThe role of CD36 in the pathophysiology of malaria: validation of a murine model and design of a clinical study
dc.typeThesis

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
MQ95459_OCR.pdf
Size:
3.38 MB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
TSpace_LAC_SGS_license_MOA2015.txt
Size:
2.45 KB
Format:
Plain Text
Description:
No Thumbnail Available
Name:
TSpace_LAC_SGS_license_MOA2015.pdf
Size:
69.65 KB
Format:
Adobe Portable Document Format
Description: