Antiinflammatory activity of ricinus communis derived polymer
Date
2009-05-13
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Piracicaba Dental School - UNICAMP
Abstract
Description
Aim: The present study aimed to evaluate the antiinflammatory
activity of the polymer derived from Ricinus communis and its mechanism
of action. Methods: The antiinflammatory activity was investigated in
chronic and acute animal models and the mechanism of action involved in
the antiinflammatory activity was determined by the in vitro
phospholipase A2 (PLA2) enzyme assay. Results: In mouse ear edema
(10.0 mg/ear) and granulomatous tissue formation (500 mg/kg) models,
the polymer inhibited the inflammatory response in 75.08 ± 1.80%
and 61.70 ± 1.80% of the cases, respectively (p<0.001). Oral
administration of the Ricinus communis polymer (500 mg/kg) inhibited
72.00 ± 1.20% of formalin-induced inflammation. Topical
administration of the polymer on oral lesions of mice showed that the
oral mucosa was recovered in 60.00 ± 1.40% (p<0.05) of the
cases. In in vitro assay, the phospholipase A2 enzyme was inhibited by
the Ricinus communis polymer (5.0 mg/mL) in a dose-dependent manner
(84.60 ± 1.41%). Conclusion: the polymer derived from Ricinus
communis showed a significant antiinflammatory activity, confirming
that the pharmacological mechanism involved in this antiinflammatory
action was related to the inhibition of the PLA2 enzyme.
Keywords
antiinflammatory activity., phospholipase A2, Ricinus communis, polymer
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