A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides

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dc.contributor.authorKhopkar, Udayen_US
dc.contributor.authorDoshi, Bhavana R.en_US
dc.contributor.authorDongre, Atul M.en_US
dc.contributor.authorGujral, Sumeeten_US
dc.date.accessioned2014-05-06T22:32:02Z
dc.date.available2014-05-06T22:32:02Z
dc.date.issued2011-10-06en_US
dc.descriptionBackground: Mycosis fungoides (MF) is cutaneous lymphoma of the T-cell lineage. Hypopigmented MF is a clinical variant of MF, described mainly in Asians. This is a retrospective clinicopathologic analysis of hypopigmented MF at a tertiary care center. Aims: To describe the clinicopathologic profile of hypopigmented MF. Methods: Records of clinicopathologic notes over a 5-year period ranging from January 2005 up to December 2009 were reviewed over a period of 3 months, of which 15 cases were diagnosed with hypopigmented MF based on clinicopathologic correlation. Results: Hypopigmented MF was found to be more common in males, and between second and fourth decades of life. The latent period between onset and diagnosis was around 3.83 years. Most of the patients were asymptomatic 80% (12/15), with skin changes of subtle atrophy in 46.66% (7/15), scaling in 20% (3/15) and focal changes of poikiloderma in 26.66% (4/15) patients. Most common sites of distribution of the lesions were the trunk and extremities. Many of the cases had been clinically mistaken for Hansen′s disease prior to correct diagnosis. Marked epidermotropism and tagging of epidermis by large lymphocytes characterizes the condition histopathologically. Of the 15 cases, immunohistochemistry was possible in 10 cases, of which 8 showed predominant CD8 positive epidermotropic infiltrates and two cases showed absence of CD8 positive and CD4 positive lymphocytic infiltrate in the epidermis. Conclusion: Hypopigmented MF presents as hypopigmented asymptomatic patches without any erythema or infiltration in its early stage and mimics Hansen′s disease. Skin biopsy clinches the diagnosis.en_US
dc.identifier.urihttp://hdl.handle.net/1807/48808
dc.identifier.urihttp://www.bioline.org.br/abstract?id=dv11046en_US
dc.identifier.urihttp://www.bioline.org.br/dven_US
dc.identifier.urihttp://www.ijdvl.comen_US
dc.languageenen_US
dc.locationOrigin of publication: Indiaen_US
dc.publication.journalIndian Journal of Dermatology, Venereology and Leprology (ISSN: 0378-6323) Vol 77 Num 2en_US
dc.publisherMedknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)en_US
dc.rights.holderCopyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.en_US
dc.subjectHansen′s diseaseen_US
dc.subjecthypopigmented mycosis fungoidesen_US
dc.subjectEpidermotropismen_US
dc.titleA study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoidesen_US
dc.typeArticleen_US

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