Association of the Cocaine- and Amphetamine-Regulated Transcript Prepropeptide Gene (CARTPT) rs2239670 Variant with Obesity among Kampar Health Clinic Patrons, Malaysia
Date
2013-01-06
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School of Medical Sciences, Universiti Sains Malaysia
Abstract
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Background: Cocaine- and amphetamine-regulated transcript (CART) is a
hypothalamic anorectic neuropeptide that controls feeding behaviour and
body weight. The study objective was to investigate the association of
the CART prepropeptide gene (CARTPT) rs2239670 variant with obesity and
its related anthropometric indicators among patients of a Malaysian
health clinic in Kampar, Perak, Malaysia. Methods: A total of 300
Malay/Peninsular Bumiputera, Chinese, and Indian subjects (115 males,
185 females; 163 non-obese, 137 obese) were recruited by convenience
sampling, and anthropometric measurements, blood pressures, and pulse
rate were taken. Genotyping was performed using AvaII polymerase chain
reaction–restriction fragment length polymorphism. Results:
Genotyping revealed 203 (67.7%), 90 (30.0%), and 7 (2.3%) subjects with
the GG, GA, and AA genotypes, respectively, with a minor allele (A)
frequency of 0.17. No significant difference in the CARTPT rs2239670
genotype and allele distribution was found between obese and non-obese
subjects, and logistic regression showed no association between the
mutated genotypes (GA, AA) and allele (A) with obesity, even after
adjusting for age, gender, and ethnicity. Furthermore, the measurements
did not differ significantly between the genotypes and alleles. No
significant difference in the genotype and allele distribution was
found among genders, but they were significantly different among
ethnicities (P = 0.030 and P = 0.019, respectively). Conclusion: CARTPT
rs2239670 is not a predictor for obesity among the Malaysian subjects
in this study.
Keywords
Malaysia, single nucleotide polymorphism, obesity, genetic association study, anthropometry, cocaine- and amphetamine-regulated transcript protein
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