Ichthyosiform mycosis fungoides with alopecia and atypical membranous nephropathy

dc.contributor.authorZhou, Qiangen_US
dc.contributor.authorZhu, Kejianen_US
dc.contributor.authorYu, Haiyanen_US
dc.contributor.authorCheng, Haoen_US
dc.date.accessioned2014-05-06T22:32:02Z
dc.date.available2014-05-06T22:32:02Z
dc.date.issued2011-10-06en_US
dc.descriptionWe describe here a rare case of variant of mycosis fungoides (MF): ichthyosiform MF with alopecia and atypical membranous nephropathy. The diagnosis was made based on the following findings: generalized ichthyosis-like eruption, alopecia, enlarged superficial lymph nodes, proteinuria, and hematuria, the histological features of the skin biopsy from both ichthyotic and alopecic lesions with immunohistochemical staining, and the renal biopsy examination with immunofluorescence. The histological examination of ichthyotic and alopecic lesions displayed a predominant infiltration of atypical lymphocytes in the upper dermis with the characteristics of epidermotropism and folliculotropism. Immunohistochemical studies demonstrated that most infiltrated atypical lymphocytes were CD3, CD4, and CD45RO positive, whereas negative for CD5, CD7, CD20, CD30, and CD56. A renal biopsy examination revealed atypical membranous nephropathy with deposition of immunoglobulin G (IgG), IgM, IgA, C1q, and C3. In this case atypical membranous nephropathy was involved, which is very uncommon and has never been presented in the literature to date. Although ichthyosiform MF usually features a relatively favorable course, diffuse alopecia and the renal involvement in this case might indicate aggressive disease and poor prognosis.en_US
dc.identifier.urihttp://hdl.handle.net/1807/48811
dc.identifier.urihttp://www.bioline.org.br/abstract?id=dv11049en_US
dc.identifier.urihttp://www.bioline.org.br/dven_US
dc.identifier.urihttp://www.ijdvl.comen_US
dc.languageenen_US
dc.locationOrigin of publication: Indiaen_US
dc.publication.journalIndian Journal of Dermatology, Venereology and Leprology (ISSN: 0378-6323) Vol 77 Num 2en_US
dc.publisherMedknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)en_US
dc.rights.holderCopyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.en_US
dc.subjectalopeciaen_US
dc.subjectnephropathyen_US
dc.subjectIchthyosiform mycosis fungoidesen_US
dc.titleIchthyosiform mycosis fungoides with alopecia and atypical membranous nephropathyen_US
dc.typeArticleen_US

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